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Table 1 Results for the maximization of X3 and v4 and optimization goals O1-O4 using BARON v.8.1.5. for a tolerance of 0.2%.

From: Steady-state global optimization of metabolic non-linear dynamic models through recasting into power-law canonical models

O

k 1

k 2

k 3

k 4

k 5

k 6

X 3

OG (%)

CPU (s)

1

0.26

5.00

4.97

0.20

0.20

0.54

8.30

0.20

136.17

2

0.20

0.24

0.22

0.20

0.21

0.20

1.10

0.00

0.06

3

0.60

5.00

5.00

0.53

0.20

0.27

5.39

0.20

96.39

4

0.99

1.15

1.00

0.96

1.00

1.00

1.10

0.00

1.42

O

k 1

k 2

k 3

k 4

k 5

k 6

v 4

OG (%)

CPU (s)

1

4.61

5.00

5.00

5.00

0.72

1.20

37.40

0.20

157.83

2

3.22

3.73

5.00

4.99

0.21

0.22

31.33

0.00

1.67

3

0.88

0.94

0.88

0.96

0.23

3.00

6.60

0.00

10.53

4

1.16

1.00

1.34

1.34

1.00

1.00

7.61

0.00

3.61