Figure 3

The heat maps of local sensitivities of each reaction flux with respect to each parameter. Each column represents a parameter, and each row represents a single reaction flux. Reactions R₁-R₂₄ represent the Bmal1 mRNA formation, Bmal1 mRNA degradation, cytosolic BMAL1 formation, cytosolic BMAL1 phosphorylation, cytosolic BMAL1 dephosphorylation, cytosolic BMAL1 nonspecific degradation, cytosolic phosphorylated BMAL1 degradation, cytosolic phosphorylated BMAL1 nonspecific degradation, BMAL1 protein entry into the nucleus, BMAL1 protein exit from the nucleus, nuclear BMAL1 nonspecific degradation, nuclear BMAL1 phosphorylation, nuclear BMAL1 dephosphorylation, nuclear phosphorylated BMAL1 degradation, Myod1 mRNA formation, Bmal1 mRNA nonspecific degradation, Myod1 mRNA degradation, Myod1 mRNA nonspecific degradation, MYOD1 formation, cytosolic MYOD1 phosphorylation, cytosolic MYOD1 dephosphorylation, cytosolic MYOD1 degradation, cytosolic phosphorylated MYOD1 degradation, cytosolic phosphorylated MYOD1 nonspecific degradation, respectively. Reactions R₃₇-R₄₅ represent the miR-206 formation, R _ISC complex formation, miR-206 degradation, R _ISC complex degradation, I _N complex formation, I _N complex dissociation, I _N complex degradation, I _N complex nonspecific degradation and nuclear phosphorylated BMAL1 nonspecific degradation, respectively. The explanation of the parameters in each column can be seen in Table 1.