Figure 1
From: The logic of kinetic regulation in the thioredoxin system
Modelling the thioredoxin system in E. coli. A kinetic model of the thioredoxin system in E. coli was developed that included reactions for the reduction of oxidized thioredoxin (TrxSS) by thioredoxin reductase (TR), the thioredoxin-dependent reductions of methionine sulfoxide (Met-S-SO) by methionine sulfoxide reductase (MsrA) and 3'-phosphoadenosine-5'-phosphosulfate (PAPS) by PAPS reductase (PR) and the Tpx-dependent reduction of hydrogen peroxide. In other systems biology approaches, electron flow pathways have been used to model this system (blue arrows). However, in our model, thioredoxin-dependent reactions were modeled as a series of moiety conserved cycles (see text for details).