Regulation of the yeast metabolic cycle by transcription factors with periodic activities

BMC Systems Biology

Table 1 List of top 13 transcription factors

TF	Periodicity	Phase	Amplitude	Function
ACE2	0.520	45°	0.048	Cell cycle (early G1 specific transcription).
ADR1	0.518	48°	0.047	Glucose repression.
ARO80	0.544	44°	0.066	Aromatic AA degradation
BAS1	0.562	293°	0.082	Recombination. Purine and histidine synthesis.
GAL3	0.452	215°	0.036	Galactose metabolism.
GCN4	0.548	2°	0.085	Main regulator of general AA control.
HAP1	0.449	80°	0.049	Respiration. Heme-responsive. Growth potential.
HAP3	0.503	255°	0.048	Respiration. Subunit of heme-activ'd Hap2/3/4/5.
HAP4	0.620	227°	0.124	Respiration. Subunit of heme-activ'd Hap2/3/4/5.
MSN4	0.595	0°	0.062	Cell cycle. Stress-responsive gene expression.
RLR1	0.515	42°	0.063	Recombination. Transcriptional elongation.
SPT2	0.497	302°	0.108	Cell cycle (interacts w/histones, SWI-SNF).
SWI6	0.631	225°	0.058	Cell cycle (progression from G1 to S phase).

Shown are the transcription factors that remain after iterative filtering for the highest periodicity scores of their α-coefficients. Phase and amplitude were calculated from the best-fit sine waves.

ISSN: 1752-0509