Skip to main content

Table 1 Analysis of cell compartment enrichment in the BIOGRID database.

From: Removing bias against membrane proteins in interaction networks

GO ID

GO Term

Median p-value

Overrepresented categories:

  

32991

macromolecular complex

4.96E-105

43234

protein complex

1.80E-78

44428

nuclear part

1.06E-66

5622

intracellular

2.74E-54

44424

intracellular part

3.72E-53

44422

organelle part

8.61E-51

44446

intracellular organelle part

8.61E-51

5634

nucleus

2.43E-52

43229

intracellular organelle

8.85E-48

43226

organelle

8.85E-48

31981

nuclear lumen

1.27E-53

44451

nucleoplasm part

5.98E-38

5654

nucleoplasm

1.75E-38

44464

cell part

3.54E-33

5623

cell

4.46E-33

43228

non-membrane-bounded organelle

1.67E-34

43232

intracellular non-membrane-bounded organelle

1.67E-34

43233

organelle lumen

1.02E-31

31974

membrane-enclosed lumen

1.02E-31

43231

intracellular membrane-bounded organelle

4.99E-31

43227

membrane-bounded organelle

4.99E-31

16591

DNA-directed RNA polymerase II, holoenzyme

4.98E-11

5694

chromosome

7.67E-15

30529

ribonucleoprotein complex

2.76E-12

5730

nucleolus

6.52E-13

502

proteasome complex

2.37E-06

44427

chromosomal part

1.61E-14

5856

cytoskeleton

3.25E-07

5679

chromatin remodeling complex

1.70E-09

123

histone acetyltransferase complex

5.87E-10

44430

cytoskeletal part

1.65E-05

22624

proteasome accessory complex

9.47E-04

5838

proteasome regulatory particle

9.47E-04

44452

nucleolar part

2.30E-08

5669

transcription factor TFIID complex

7.26E-03

5681

spliceosome

4.85E-04

119

mediator complex

3.91E-04

124

SAGA complex

1.04E-05

5667

transcription factor complex

3.06E-04

812

SWR1 complex

1.15E-03

44453

nuclear membrane part

6.00E-03

Underrepresented categories:

943

retrotransposon nucleocapsid

2.88E-05

31224

intrinsic to membrane

1.22E-05

44429

mitochondrial part

3.18E-04

5740

mitochondrial envelope

4.89E-03

16021

integral to membrane

7.67E-05

44425

membrane part

1.85E-03

5743

mitochondrial inner membrane

7.18E-03

5739

mitochondrion

6.34E-03

  1. The median p-values were calculated after sampling 10 random sets of 1000 interactions from BIOGRID. P-values are shown after Bonferroni's correction for multiple hypotheses.