Table 2 Correlation between membrane interaction content and centrality-lethality rule for different PPI techniques.
From: Removing bias against membrane proteins in interaction networks
Technique | Unique interactions | Fraction of membrane interactions | Kendall's tau | Kendall's tau (p-value) | Indess (5) | Assortativity coefficient |
|---|---|---|---|---|---|---|
Affinity Capture-MS | 26350 | 0.14 | 0.277 | 9.46E-96 | 1.864 | -0.071 |
Co-localization | 351 | 0.18 | 0.181 | 4.14E-04 | 1.996 | 0.214 |
Co-purification | 1217 | 0.28 | 0.127 | 1.07E-04 | 1.558 | -0.227 |
Reconstituted Complex | 1959 | 0.29 | 0.167 | 3.49E-11 | 2.069 | -0.101 |
Two-hybrid (without Miller et al (2005)) | 7040 | 0.29 | 0.141 | 9.11E-20 | 1.657 | -0.107 |
Affinity Capture-Western | 4953 | 0.30 | 0.188 | 3.92E-24 | 1.894 | 0.112 |
BIOGRID (all techniques) | 94877 | 0.30 | 0.190 | 4.98E-70 | 1.312 | -0.102 |
Affinity Capture-RNA | 1187 | 0.31 | 0.119 | 5.07E-05 | 1.833 | -0.857 |
Biochemical Activity | 5355 | 0.31 | -0.034 | 0.104 | 0.792 | -0.460 |
Co-fractionation | 574 | 0.58 | 0.044 | 0.274 | 0.833 | -0.163 |
PF-PCA | 2395 | 0.65 | 0.018 | 0.505 | 0.904 | 0.171 |
SU-2HY | 1941 | 0.99 | -0.004 | 0.928 | 1.187 | -0.074 |