From: Complex receptor-ligand dynamics control the response of the VEGF system to protease injury
Symbol | Value | Meaning |
---|---|---|
R1(t = 0) | 65,000 #/cell | # of VEGFR1 per cell at time zero |
R2(t = 0) | 12,000 #/cell | # of VEGFR2 per cell at time zero |
N(t = 0) | 10,000 #/cell | # of Neuropilin-1 per cell at time zero |
E(t = 0) | 1,000,000 #/cell | # of ECM sites per cell which can bind VEGF at time zero |
| 3 × 107 M-1 s-1; 1 × 10-3 s-1 | Association/dissociation rate constant for VEGF binding to VEGFR1 |
| 1 × 107 M-1 s-1; 1 × 10-3 s-1 | Association/dissociation rate constant for VEGF binding to VEGFR2 |
| 4.2 × 105 M-1 s-1; 1 × 10-2 s-1 | Association/dissociation rate constant for VEGF binding to ECM (based on HS values from literature) |
| 3.125 × 106 M-1 s-1; 1 × 10-3 s-1 | Association/dissociation rate constant for VEGF binding to NP-1 |
| 3 × 107 M-1 s-1; 1 × 10-3 s-1 | Association/dissociation rate constant for VEGFf binding to VEGFR1(modeled the same as VEGF) |
| 3.1 × 1013 (mol/cm2)-1 s-1; 1 × 10-3 s-1 | Coupling/uncoupling rate constant for VEGF-VEGFR2 with NP-1 |
| 1 × 1014 (mol/cm2)-1 s-1; 1 × 10-2 s-1 | Coupling/uncoupling rate constant for VEGFR1 with NP-1 |
| 1 × 1014 (mol/cm2)-1 s-1; 1 × 10-3 s-1 | Coupling/uncoupling rate constant for VEGF-NP-1with VEGFR2 |
|
| Association/dissociation rate constant for VEGFf binding to VEGFR1-NP-1 |
|
| Coupling/uncoupling rate constant for VEGFf-VEGFR1 with NP-1 |
k int | 2.8 × 10-4 s-1 | Internalization rate for unbound receptors |
| 2.8 × 10-4 s-1 | Internalization rate for VEGF-bound receptors |
| 2.8 × 10-4 s-1 | Internalization rate for VEGFf-bound receptors |
S I | k int I 0 | Synthesis rate for species I where I0 is the initial concentration of I |