Inferring pleiotropy by network analysis: linked diseases in the human PPI network

Nguyen, Thanh-Phuong; Liu, Wei-chung; Jordán, Ferenc

doi:10.1186/1752-0509-5-179

BMC Systems Biology

Table 5 Centrality ranks in the total network.

From: Inferring pleiotropy by network analysis: linked diseases in the human PPI network

	nD		nCC		nBC		TI³		TO³_0.01		TO³_0.005
P62993	30.23	P62993	46.11	P62993	36.84	P62993	278.83	P62993	8381	P62993	23017
P63104	19.10	P12931	44.07	P63104	25.10	P63104	201.37	P12931	6791	P63104	22032
P06241	15.81	P22681	43.81	P12931	13.34	P06241	118.70	P63104	6489	P12931	21112
P12931	14.28	P00533	43.04	P17252	13.07	P12931	101.69	P06241	5322	P49407	19777
P49407	10.00	P06241	42.16	P49407	12.99	P49407	98.76	P17252	2966	P06241	19449
P17252	9.96	Q13813	42.00	P06241	12.50	P62736	95.29	P28482	2240	P17252	19070
P62736	9.51	P17252	41.64	P62736	11.36	P17252	88.26	P07948	2084	P62736	17788
P28482	8.78	P63104	41.38	P02768	10.53	P02768	86.12	P62736	1818	P22681	13383
P27361	7.03	P00519	41.20	P28482	9.33	P28482	68.56	P49407	1784	P28482	13267
P02768	6.94	P21333	41.12	P22681	5.49	P27361	51.72	P27361	1734	P07948	12041
P22681	5.27	P28482	41.10	P27361	5.11	P22681	36.87	P22681	1628	P27361	8970
P07948	5.18	P07355	40.88	Q03135	4.51	Q03135	36.27	P05129	944	Q03135	8488
Q03135	4.37	P61978	40.67	P07948	3.22	P07948	35.12	P41240	677	P41240	7515
P41240	2.70	Q02156	40.28	Q5JY77	2.91	Q5JY77	24.85	P13500	559	P09471	4708
P05129	2.34	P29353	40.26	O14908	2.60	O14908	22.16	Q03135	552	O14908	4366
P05106	2.30	O14939	40.12	P09471	2.15	Q99962	18.30	P08254	525	Q5JY77	4319
Q5JY77	2.16	P62988	40.12	Q99962	2.01	P05106	18.15	P03956	511	P08588	4194
O14908	2.12	P43405	40.00	P05106	1.91	P09471	18.11	P05106	497	P05129	3488
Q99962	1.94	Q06124	39.99	P41240	1.45	P05129	17.16	P80075	444	P05106	3468
P09471	1.58	O43707	39.91	P00533	0.90	P41240	15.63	P80098	444	P04629	3288
P13500	0.90	P07900	39.86	P07550	0.89	Q14232	8.00	Q99616	438	P98164	3193
O14788	0.86	Q07889	39.82	Q9UBS5	0.83	P48745	6.63	P51681	435	P41143	2733
P80098	0.77	P49407	39.78	P05129	0.80	O14788	5.75	O14788	412	P35372	2721
Q14232	0.77	P06213	39.71	P18545	0.76	P13500	5.57	O00590	400	P07550	2551
P48745	0.59	P56945	39.58	P06396	0.75	P80098	5.25	P39900	400	P49795	2464
P00533	0.50	P06396	39.57	Q14232	0.74	P54646	5.07	P41597	400	P08648	2456
P80075	0.50	Q15746	39.50	P48745	0.73	P80075	2.48	P51677	400	Q08116	2452
P54646	0.45	Q05655	39.39	O14788	0.73	Q99616	2.38	Q9NPB9	400	P41594	2155
Q99616	0.45	P11142	39.31	P13500	0.71	P00533	2.12	P32246	373	P08069	1854
P29353	0.41	P35568	39.24	P61981	0.66	P29353	1.57	Q16570	373	P98082	1810

The rank of the most central 30 nodes in the total network, based on the six importance indices analyzed.

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ISSN: 1752-0509

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