Figure 3

Reactions and pathways that were found to be different when comparing FVA profiles for the healthy individuals as compared to the HHT patient (prior to bevacizumab treatment). Green fluxes represent increased flux span ratios and red fluxes represent decreased flux span ratios, for a non-HTT individual compared to an individual with HHT (e.g. red colored reactions indicate pathways with increased flux spans and maximum fluxes in HHT). Yellow shaded reactions demarcate reactions with intermediate changes in flux span ratios. Abbreviations: NOS1/NOS2: Nitric Oxide Synthase, NO: nitric oxide, arg-L: L-arginine, ser-L: L-serine, gly: glycine (in cytosol), gly[m]: glycine (in mitochondria), glu-L: L-glutamate, gthrd: glutathione (reduced), gthox: glutathione (oxidized).