Isoforms Involved | Reaction | Forward kon, kc, kint | Reverse koff, kuc | Keq | Ref. |
---|---|---|---|---|---|
 | Cell-surface Reactions |  |  |  |  |
121, 165 | Binding VEGF to VEGFR2 | 1·107 M-1s-1 | 0.001 s-1 | 100 pM | [42] |
All | Binding VEGF to VEGFR1 | 3·107 M-1s-1 | 0.001 s-1 | 33.3 pM | [42] |
165, 189 | Binding VEGF to NRP1 | 3.2·106 M-1s-1 | 0.001 s-1 | 312 pM | [42] |
165 | Binding VEGF165-VEGFR2 to NRP1 | 3.1·106 [1015 μm2/(mol·s)] | 0.001 s-1 | 323 mol/1015 μm2 | [42] |
165 | Coupling VEGF165-NRP1 to VEGFR2 | 1·107 [1015 μm2/(mol·s)] | 0.001 s-1 | 100 mol/1015 μm2 | [42] |
121, Cleaved | Coupling VEGFR1 to NRP1 or Coupling VEGF114-VEGFR1 to NRP1 | 1·107 [1015 μm2/(mol·s)] | 0.01 s-1 | 1000 mol/1015 μm2 | [42] |
- | Internalization, kint | 2.8·10-4 s-1 | - | - | [42] |
- | Insertion, sR2, sR1, or sN1 | e.g., kint.·[R2]total | - | - | calculated |
 | ECM Reactions |  |  |  |  |
165 | VEGF165 to HSPG | 6.06·104 M-1s-1 | 0.01 s-1 | 165 nM | [63] |
189 | VEGF189 to HSPG | 1.18·106 M-1s-1 | 0.01 s-1 | 8.5 nM | Figure S1.1 |
All | Degradation rate, kdeg (only Figs. 4C,D; 8A) | 0.001 s-1 | - | - | assumed |
All | Protease activity, kP (only Figs. 6; 7A; 8A) | 2.8·10-4 s-1 | - | - | assumed |