Skip to main content

Table 3 Interpretation and validation information of the significant GO term gene sets inferred by GAGE

From: Time series gene expression profiling and temporal regulatory pathway analysis of BMP6 induced osteoblast differentiation and mineralization

GO terms

Perturbation

References

Other evidence

Notch signaling pathway

8h-10d up

[11, 25]

--

insulin-like growth factor receptor binding

8h-10d up

[26, 27]

--

insulin-like growth factor binding

10d down

[28–31]

--

homophilic cell adhesion

24h-96h up

[34]

--

immune response

96h-10d down

[32, 33]

--

skeletal development

8h-96h up

--

--

ossification

96h-10d up

--

--

oxidoreductase activity

8h-24h, 10d down

[35]

--

selenium binding

96h-10d up

--

--

  1. Temporal perturbation patterns (significantly perturbed time period and the direction), supportive literature and experimental evidence all suggest the regulatory roles of these GO terms in BMP6 induced osteoblast differentiation and mineralization.