Figure 2

Sub-network #10: MYC target genes. A) The sub-network of MYC target genes. Nodes represent gene sets and edges represent significant overlaps. The size of the node indicates the number of genes in the gene set, which is also numerically labelled by the number at the end of each gene set name. The thickness of the edges is proportional to significance (-log10(FDR)). The labels of edges indicate the number of overlapping genes. Red dashed edges represent repressive connections between "X" upregulated genes and "Y" downregulated genes. The same settings were used to generate subsequent figures in this paper. Gene sets explicitly related to MYC oncoprotein are highlighted in yellow. B) List of 15 genes (columns) that appear three times or more in these seven gene sets (rows). Red indicates that a gene is included in a gene set. This figure shows that our approach can identify overlaps between biologically related gene signatures.