Table 1 Hub list for breast cancer study (GSE2990 and GSE6532) histological grade 1 and 3

Up-regulated in endometrial cancer by the inducer of myometrial infiltration ERM/ETV5 [55]; Protective role against oxidative-stress induced apoptosis in endometrial cancer [55]; Down-regulated in ovarian tumors following cisplatin treatment [32]

Overexpression in breast cancer tumor tissue, with elevated blood serum levels in patients with metastatic disease [56]

Overexpressed in subset of estrogen-receptor positive breast cancer; Ectopic overexpression confers a highly invasive phenotype in primary mammary epithelial cells; AGTR1-positive tumor growth reduced by 30% with receptor blockade in xenograft model [54]

Expressed in breast cancer tissue compared to normal breast tissue [57]; Expression associated with increased risk of post-operative breast cancer recurrence [58]

Overexpressed in breast cancer tissue [59]; Associated with mammary gland proliferation and terminal differentiation [60]

Breast tumor transfection of MMP12 reduced endothelial cell invasion and capillary tube formation [50]

Estrogen-regulated gene expressed in hormone-responsive breast cancer [61]; Correlated with estrogen receptor phenotype [62]; Suppressed with tamoxifen and aromatase inhibitors [63]

BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines. [64]

siRNA-mediated knockdown of S100A8/A9 expression significantly reduced H-Ras-induced invasion/migration; Induction confers the invasive/migratory phenotype [52]; Immunopositivity correlates with mitotic activity, MIB-1 index, HER2 overexpression, node metastasis, and poor prognosis [65]; Associated with transformation and progression of breast cancer cells which is reversed by treatment with silencing inhibitors [53]; Down-regulated in invasive tumors [66]

Differentially expressed in hill-type cancer cells [67]