Figure 1
From: Towards a quantitative understanding of the MITF-PIAS3-STAT3 connection
Overview of the modelled network. The two transcription factors MITF and STAT3 are phosphorylated by the MAPK-pathway and the JAK-STAT-pathway, respectively. PIAS3 inhibits their activity as transcription factors by binding and forming inactive complexes. The abundance of one transcription factor can sequester PIAS3 to depletion, and eliminate the inhibition of the other transcription factor.