Table 5 Combinations of constitutive activations and inactivations putatively leading to carcinogenesis

1

[0]PP5

& [0]PIDD-RAIDD-caspase2

2

[0]PP5

& [0]IkappaBalpha

3

[0]PP5

& [0]PIDD

4

[0]PP5

& [0]Hsp90

5

[0]PP5

& [1]p90-P

6

[0]PP5

& [2]IKK_complex-P

7

[0]PP5

& [1]MEK-P

8

[0]PP5

& [1]ERK-P

9

[0]PP5

& [1]cytosolic_p50-p65

10

[0]PP5

& [1]nuclear_p50-p65-P

11

[0]PP5

& [1]TAK1-P

12

[1]Wip1

& [0]Hsp90

13

[1]Wip1

& [0]IKK_complex-P

& [0]PIDD-RAIDD-caspase2

14

[1]Wip1

& [0]PIDD

& [0]IKK_complex-P

15

[1]Wip1

& [0]IKK_complex-P

& [1]cytosolic_p50-p65

16

[1]Wip1

& [0]IKK_complex-P

& [1]nuclear_p50-p65-P

17

[0]ATM-P

& [0]Hsp90

& [0]Chk2-P

18

[0]ATM-P

& [1]PP2A-Bx

& [0]PIDD-RAIDD-caspase2

19

[0]ATM-P

& [1]PP2A-Bx

& [0]IkappaBalpha

20

[0]PIDD

& [0]ATM-P

& [1]PP2A-Bx

21

[0]FHIT

& [0]ATM-P

& [0]Hsp90

22

[0]ATM-P

& [0]Hsp90

& [1]PP2A-Bx

23

[1]p90-P

& [0]ATM-P

& [1]PP2A-Bx

24

[0]ATM-P

& [1]PP2A-Bx

& [2]IKK_complex-P

25

[0]ATM-P

& [1]MEK-P

& [1]PP2A-Bx

26

[0]ATM-P

& [1]ERK-P

& [1]PP2A-Bx

27

[0]ATM-P

& [1]cytosolic_p50-p65

& [1]PP2A-Bx

28

[0]ATM-P

& [1]nuclear_p50-p65-P

& [1]PP2A-Bx

29

[0]ATM-P

& [1]TAK1-P

& [1]PP2A-Bx

30

[0]Chk2-P

& [0]BARD1-BRCA1-P

& [1]PP2A-Bx

31

[0]MRN

& [0]Hsp90

& [0]Chk2-P

32

[0]Hsp90

& [0]Chk2-P

& [0]p53-PS15-PS20

33

[0]Chk2-P

& [1]PP2A-Bx

& [0]p53-PS15-PS20

34

[1]MDMX

& [0]Hsp90

& [0]Chk2-P

35

[1]MDM2

& [0]Chk2-P

& [0]Hsp90

36

[0]Hsp90

& [0]Chk2-P

& [1]PP2A-B55

37

[1]PP1

& [0]Chk2-P

& [0]Hsp90

38

[1]MDMX

& [0]Chk2-P

& [1]PP2A-Bx

39

[1]MDM2

& [0]Chk2-P

& [1]PP2A-Bx

40

[1]PP1

& [0]Chk2-P

& [1]PP2A-Bx

41

[0]MRN

& [1]PP2A-Bx

& [0]PIDD-RAIDD-caspase2

42

[1]Wip1

& [0]PIDD-RAIDD-caspase2

& [0]importin_alpha-1-beta-1

43

[1]Wip1

& [0]claspin-P

& [0]PIDD-RAIDD-caspase2

44

[1]Wip1

& [1]Cdc25A

& [0]PIDD-RAIDD-caspase2

45

[1]Wip1

& [1]Cdk2

& [0]PIDD-RAIDD-caspase2

46

[1]Wip1

& [2]IkappaBalpha

& [0]PIDD-RAIDD-caspase2

47

[1PP2A-Bx

& [1]PP2A-B55

& [0]PIDD-RAIDD-caspase2

48

[1]Wip1

& [1]PP2A-Bx

& [0]PIDD-RAIDD-caspase2

49

[0]FHIT

& [1]PP2A-Bx

& [0]BARD1-BRCA1-P

50

[0]MRN

& [1]PP2A-Bx

& [0]IkappaBalpha

51

[0]MRN

& [0]PIDD

& [1]PP2A-Bx

52

[0]MRN

& [0]FHIT

& [0]Hsp90

53

[0]MRN

& [0]Hsp90

& [1]PP2A-Bx

54

[0]MRN

& [1]p90-P

& [1]PP2A-Bx

55

[0]MRN

& [1]PP2A-Bx

& [2]IKK_complex-P

56

[0]MRN

& [1]MEK-P

& [1]PP2A-Bx

57

[0]MRN

& [1]ERK-P

& [1]PP2A-Bx

58

[0]MRN

& [1]PP2A-Bx

& [1]cytosolic_p50-p65

59

[0]MRN

& [1]PP2A-Bx

& [1]nuclear_p50-p65-P

60

[0]MRN

& [1]TAK1-P

& [1]PP2A-Bx

61

[1]Wip1

& [0]claspin-P

& [0]IkappaBalpha

62

[1]Wip1

& [1]Cdc25A

& [0]IkappaBalpha

63

[1]Wip1

& [1]Cdk2

& [0]IkappaBalpha

64

[1]PP2A-Bx

& [1]PP2A-B55

& [0]IkappaBalpha

65

[1]Wip1

& [1]PP2A-Bx

& [0]IkappaBalpha

66

[1]Wip1

& [0]PIDD

& [0]importin_alpha-1-beta-1

67

[1]Wip1

& [1]nuclear_p50-p65-P

& [0]importin_alpha-1-beta-1

68

[0]FHIT

& [0]Hsp90

& [0]p53-PS15-PS20

69

[0]FHIT

& [1]PP2A-Bx

& [0]p53-PS15-PS20

70

[1]Wip1

& [0]PIDD

& [0]claspin-P

71

[1]Wip1

& [0]PIDD

& [1]Cdc25A

72

[1]Wip1

& [0]PIDD

& [1]Cdk2

73

[1]Wip1

& [0]PIDD

& [2]IkappaBalpha

74

[0]PIDD

& [1]PP2A-Bx

& [1]PP2A-B55

75

[1]Wip1

& [0]PIDD

& [1]PP2A-Bx

76

[0]FHIT

& [1]MDMX

& [0]Hsp90

77

[0]FHIT

& [1]MDM2

& [0]Hsp90

78

[0]FHIT

& [0]Hsp90

& [1]PP2A-B55

79

[1]PP1

& [0]FHIT

& [0]Hsp90

80

[0]Hsp90

& [1]PP2A-Bx

& [1]PP2A-B55

81

[0]FHIT

& [1]MDMX

& [1]PP2A-Bx

82

[0]FHIT

& [1]MDM2

& [1]PP2A-Bx

83

[1]PP1

& [0]FHIT

& [1]PP2A-Bx

84

[1]Wip1

& [1]p90-P

& [0]claspin-P

85

[1]Wip1

& [0]claspin-P

& [2]IKK_complex-P

86

[1]Wip1

& [1]MEK-P

& [0]claspin-P

87

[1]Wip1

& [1]ERK-P

& [0]claspin-P

88

[1]Wip1

& [0]claspin-P

& [1]cytosolic_p50-p65

89

[1]Wip1

& [0]claspin-P

& [1]nuclear_p50-p65-P

90

[1]Wip1

& [1]p90-P

& [1]Cdc25A

91

[1]Wip1

& [1]Cdk2

& [1]p90-P

92

[1]p90-P

& [1]PP2A-Bx

& [1]PP2A-B55

93

[1]Wip1

& [1]p90-P

& [1]PP2A-Bx

94

[1]Wip1

& [1]Cdc25A

& [2]IKK_complex-P

95

[1]Wip1

& [1]Cdk2

& [2]IKK_complex-P

96

[1]PP2A-Bx

& [1]PP2A-B55

& [2]IKK_complex-P

97

[1]Wip1

& [1]PP2A-Bx

& [2]IKK_complex-P

98

[1]Wip1

& [1]MEK-P

& [1]Cdc25A

99

[1]Wip1

& [1]ERK-P

& [1]Cdc25A

100

[1]Wip1

& [1]Cdc25A

& [1]cytosolic_p50-p65

101

[1]Wip1

& [1]Cdc25A

& [1]nuclear_p50-p65-P

102

[1]Wip1

& [1]Cdk2

& [1]MEK-P

103

[1]Wip1

& [1]Cdk2

& [1]ERK-P

104

[1]Wip1

& [1]Cdk2

& [1]cytosolic_p50-p65

105

[1]Wip1

& [1]Cdk2

& [1]nuclear_p50-p65-P

106

[1]MEK-P

& [1]PP2A-Bx

& [1]PP2A-B55

107

[1]Wip1

& [1]MEK-P

& [1]PP2A-Bx

108

[1]ERK-P

& [1]PP2A-Bx

& [1]PP2A-B55

109

[1]Wip1

& [1]ERK-P

& [1]PP2A-Bx

110

[1]Wip1

& [2]IkappaBalpha

& [1]cytosolic_p50-p65

111

[1]Wip1

& [2]IkappaBalpha

& [1]nuclear_p50-p65-P

112

[1]PP2A-Bx

& [1]PP2A-B55

& [1]cytosolic_p50-p65

113

[1]Wip1

& [1]PP2A-Bx

& [1]cytosolic_p50-p65

114

[1]PP2A-Bx

& [1]PP2A-B55

& [1]nuclear_p50-p65-P

115

[1]TAK1-P

& [1]PP2A-Bx

& [1]PP2A-B55

116

[1]Wip1

& [1]PP2A-Bx

& [1]nuclear_p50-p65-P

117

[1]Wip1

& [1]TAK1-P

& [1]PP2A-Bx