Figure 1
From: A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation
(A-F) The response of the model to changes in the intake of dietary cholesterol compared to a published meta-analysis. A) The relationship between mean change in dietary cholesterol (mg/day) and mean change in plasma cholesterol levels (mg/dL) in 167 cholesterol feeding studies published between 1960 and 1999 (McNamara 2000). B-D) The response of the model to changes in dietary cholesterol over a range of time periods. E) Steady-state levels of LDL-C for various different intakes of dietary cholesterol. F) The change in LDL-C levels in response to various different values of the parameter k 1 (cholesterol ingestion). Results of both E&F were generated from a sensitivity analysis of the model using the software tool Copasi.