Table 2 Summary of the reactions and parameter values used in the model
From: A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation
Reaction | Parameter | Value | Units |
|---|---|---|---|
Cholesterol intake | k 1 | 1 | mg/day |
Bile salt release | k 2 | 6 | mg/day |
Hepatic return of bile salts | k 3 | 4.29 | mg/day |
Bile salt excretion | k 4 | 8.56 × 10-1 | mg/day |
Bile salt synthesis | k 5 | 2.66 | mg/day |
Cholesterol absorption | k 6 | 5.29 × 10-4 | mg/day |
Cholesterol excretion | k 7 | 5.29 × 10-4 | mg/day |
Intestinal Nascent HDL synthesis | k 8 | 5 × 10-4 | mg/day |
Hepatic cholesterol storage | k 9 | 1 | mg/day |
Release of stored Hepatic cholesterol | k 10 | 5.998 | mg/day |
Hepatic Nascent HDL Synthesis | k 11 | 5 × 10-2 | mg/day |
VLDL cholesterol formation | k 12 | 1.6 × 10-2 | mg/dL/day |
Synthesis of hepatic LDL receptors | k hrs | 100 | number/day |
Hepatic LDL receptors degradation | k 13 | 1 × 10-3 | number/day |
VLDL cholesterol hepatic reuptake | k 14 | 4.96 × 10-3 | mg/dL/day |
IDL cholesterol formation | k 15 | 4.3 × 10-1 | mg/dL/day |
IDL cholesterol hepatic reuptake | k 16 | 5.4 × 10-2 | mg/dL/day |
LDL cholesterol formation | k 17 | 3.8 × 10-1 | mg/dL/day |
Hepatic LDL receptors uptake of LDL-cholesterol | k 18 | 6.80 × 10-2 | mg/dL/day |
Hepatic receptor independent uptake of LDL-cholesterol | k 19 | 5.0 × 10-3 | mg/dL/day |
Peripheral LDL receptors uptake of LDL-cholesterol | k 20 | 6.75 × 10-3 | mg/day/day |
Peripheral independent uptake of LDL-cholesterol | k 21 | 5.0 × 10-6 | mg/dL/day |
Synthesis of peripheral LDL receptors | k prs | 100 | number/day |
Peripheral LDL receptors degradation | k 22 | 1 × 10-2 | number/day |
Peripheral cholesterol storage | k 23 | 1.75 × 10-2 | mg/day |
Release of stored peripheral cholesterol | k 24 | 1.07 × 10-1 | mg/day |
Peripheral steroid production | k 25 | 5 × 10-4 | mg/day |
HDL cholesterol formation | k 26 | 1.5 × 10-5 | mg/dL/day |
CETP mediated transfer of cholesterol to VLDL from HDL | k 27 | 10 × 10-3 | mg/dL/day |
CETP mediated transfer of cholesterol to LDL from HDL | k 28 | 1 × 10-3 | mg/dL/day |
Reverse cholesterol transport | k 29 | 5.0 × 10-2 | mg/dL/day |
Maximum rate of intestinal cholesterol synthesis | ICSmax | 1 × 102 | mg/day |
Intestinal cholesterol synthesis threshold | ICSt | 3.120 × 102 | mg/day |
Sensitivity of intestinal cholesterol synthesis | IS | 5 | Fitting parameter |
Maximum rate of biliary cholesterol release | BCRmax | 2 × 103 | mg/day |
Biliary cholesterol release threshold | BCRt | 5.55 × 104 | mg/day |
Sensitivity of the feedback equation for biliary cholesterol | BS | 5 | Fitting parameter |
Maximum rate of hepatic cholesterol synthesis | HCSmax | 5 × 102 | mg/day |
Sensitivity of hepatic cholesterol synthesis | HS | 5 | Fitting parameter |
Hepatic cholesterol synthesis threshold | HCSt | 9.39 × 104 | mg/day |
Maximum rate of peripheral cholesterol synthesis | PCSmax | 5 × 102 | mg/day |
Peripheral cholesterol synthesis threshold | PPCt | 8.0342 × 104 | mg/day |
Sensitivity of peripheral cholesterol synthesis | PCSS | 5 | Fitting parameter |