Table 6 Outlining how the concentration of cholesterol in the liver was determined (Non obese subjects (n=19))
From: A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation
Liver sample | Liver homogenate | Liver microsomes | Total |
|---|---|---|---|
Mean free cholesterol | 42.4 nmol/mg | 24.7 nmol/mg | 67.1 nmol/mg |
Mean esterified cholesterol | 9.9 nmol/mg | 8.6 nmol/mg | 18.5 nmol/mg |
Total Hepatic Cholesterol | 115.6 nmol/mg | ||
Molecular weight of cholesterol | 386.66 | Used to convert nmol to milligrams | |
∴ | Total cholesterol | 44.6979 μg/mg or 0.0446979 mg/mg | |
Total esters | 7.1539 μg/mg or 0.0071532 mg/mg | ||
∴ | Total free cholesterol | 37.5447 μg/mg or 0.0375447 mg/mg | |
Size of Human Liver = 1.5 kg[89] | 1.5kg=1500000 mg | ||
0.0446979 *1500000=67046.85 mg total cholesterol | |||
0.0071532 * 1500000=10792.80 mg of cholesterol esters | |||
0.0375447*1500000=56317.5 mg of free cholesterol | |||