Figure 10From: Modeling of human factor Va inactivation by activated protein CReaction Scheme of APC Inactivation of FVa in the Presence of Either FXa or Prothrombin. Schematic of reactions and interactions involved in the APC inactivation of FVa when in the presence of either FXa (highlighted in blue and red) or prothrombin (highlighted in green). The interaction highlighted in red was identified in this study through the validation of the mathematical model describing the APC inactivation of FVa. Formation of the prothrombinase plus prothrombin species (Table 3, Eqns 19–22) and their dissociation (Table 3, Eqns 23–24) are not shown in this figure for clarity.Back to article page