Figure 6From: Modeling of human factor Va inactivation by activated protein CStructural Simulations of the Prothrombinase Complex. Top and front views of the structural simulations of the prothrombinase complex from three separate groups: Left,[52], Center[53], Right[54]. In the three models the FXa structures (presented in light blue) are based on previously solved crystal structures [PDB ID: 1XKA] [55]. In all three simulations, the FVa domain orientation is based on the crystal structure of bovine inactivated FVai (FVa1-306FVaLC) solved by Adams et al. [PDB ID: 1SDD] [56]. The FVa1-306 fragment is presented in purple, the FVaLC is presented in green, and the hypothetical structure of FVa307-709, which is based on the homology comparisons to the structure of human ceruloplasmin [PDB ID: 1KCW] [57], is presented in orange. The Arg306 residue is marked in red and encircled by a red circle and with the Arg506 residue in black and encircled by a black circle; dashed circles indicate the residue in question is completely masked by a structure from the presented view point.Back to article page