Figure 8From: Modeling of human factor Va inactivation by activated protein CEffect of Prothrombinase Components on APC Proteolysis of FVa. Normalized densitometry data measuring the disappearance of the FVaHC are from reactions containing 20 μM PC:PS, 2.0 nM APC and 20 nM FVa (filled circles, N = 6), with either 30 nM active site blocked FXa (open circles, N = 5), 1.4 μM prothrombin (filled triangles, N = 4), or 30 nM active site blocked FXa + 1.4 μM prothrombin (open triangles, N = 4). Solid lines are fits of the empirical data to monophasic exponential decay curves (FVa, FVa + FXa*, and FVa + PT) or a linear decay (FVa + FXa* + PT).Back to article page