Figure 1

Performance comparison without parameter sensitivities. Performance comparison for integration of ODE-based systems biology models without parameter sensitivities. (A) Computation times, (B) number of integration steps, (C) number of r.h.s. evaluations f(x), and (D) number of evaluations of the Jacobian J _f (x)as a function of the relative numerical tolerance. Symbols specify the integrators ode15s (open red squares), radau5 (open green diamonds), odeSD (open black circles), and odeSD _mex (filled black circles), respectively. Performance metrics are normalized to the corresponding measures for cvode and averaged (mean ±std.) over all models, which were integrated over the time spans given in Table 2; the dashed line indicates performance equal to cvode. (E) Computation times and (F) number of integration steps as a function of numerical precision (see main text for definition) in analogy to (A) and (B).