Table 3 Top 10 up-regulated glycoproteins in HOS/143B model
From: A systems biology approach reveals common metastatic pathways in osteosarcoma
Gene Symbol | Accession # | HOS/143B | p-value | Unique Peptides | Function |
|---|---|---|---|---|---|
CANX (cDNA FLJ55574) | IPI00020984 | 32 | 1.8 x 10E-9 | 7 | Molecular chaperone and protein translation quality control machinery |
RPSAP55 | IPI00399077 | 32 | 1.8 x 10E-9 | 2 | Uncharacterized |
YWHAQ | IPI00018146 | 32 | 1.8 x 10E-9 | 2 | Regulation of a large spectrum of signaling pathway |
ENO1 | IPI00465248 | 25 | 3.2 x 10E-7 | 8 | Role in glycolysis, growth control, and hypoxia tolerance |
LDHB | IPI00219217 | 23 | 9.2 x 10E-7 | 9 | Catalyzes the interconversion of pyruvate and lactate |
EIF4A3 | IPI00009328 | 23 | 9.2 x 10E-7 | 2 | ATP-dependent RNA helicase |
GAPDH | IPI00219018 | 29 | 9.4 x 10E-9 | 9 | Role in glycolysis, transcription, RNA transport, DNA replication and apoptosis |
EIF3 | IPI00012795 | 18 | 2.5 x 10E-5 | 4 | Required for several steps in the initiation of protein synthesis |
GLUD1 | IPI00016801 | 16 | 7.7 x 10E-5 | 5 | Deamination of glutamate and role in energy homeostasis |
PSME1 | IPI00479722 | 16 | 7.7 x 10E-5 | 4 | Immunoproteasome assembly and efficient antigen processing |