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Table 2 Feature analysis of proteins in unstable class

From: Mapping the stabilome: a novel computational method for classifying metabolic protein stability

Unstable vs  Stable Plus Non-Assigned

Domain/Motif

E-value

Transmembrane

3.75e-96 ‡

Signal Peptide

9.15e-50 ‡

Loops/Coils

1.36e-06

Immunoglobulin

1.77e-04

Immunoglobulin Like

2.01e-03 ‡

Immunoglobulin C

4.286e-03 ‡

Zinc Finger C2

1.73e-02

Cadherin

2.39e-02 ‡

PTM

 

Phosphorylation

2.29e-15

Acetylation

6.15e-13

Glycosylation

9.73e-04 ‡

Disorder

 

Hot loops: 0-20%

8.77e-03 ‡

Loops/Coils: 20-40%

1.06e-03

Hot loops: 20-40%

9.11e-06

Rem465: 20-40%

3.41e-05

N-degron

4.86e-80 ‡

  1. Feature types found to be significantly (Fisher’s Exact test, E-value < 0.05) over-/under-represented in the unstable protein class when compared to stable and non-assigned proteins. E-values for over-represented features are indicated with the symbol ‡, otherwise the E-value represents an under-representation. Features include domain/architecture types, PTMs, and disorder classifications based on three disorder types (loops/coils, hotloops and rem465) and percentage of sequence containing the disorder type. Lastly, the presence of a destabilizing N-terminal residue is shown, defined as the N-terminal residue of a mature protein being one of R, K, H, F, L, W, I or Y. These results are from the full data set (without removal of transmembrane or secreted proteins).
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BMC Systems Biology

ISSN: 1752-0509

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