Figure 3From: Computational analysis of calcium signaling and membrane electrophysiology in cerebellar Purkinje neurons associated with ataxiaIncreasing IP3R1 sensitivity to IP3 can restore normal calcium response in the context of reduced IP3R1 levels (a model of SCA15/16). a, Coincident calcium release (from 4 parallel fiber stimuli and a single climbing fiber stimulus) with IP3R1 levels decreased to 50% and 10%. b, Wild type levels of supralinear calcium release can be regained in IP3R1 insufficiency by augmenting IP3R1 sensitivity to activation by IP3, using IC4 at a concentration that gives a 1.7-fold increase in IP3R1 sensitivity to IP3. This fold increase in sensitivity is within an experimentally observed range (2-fold) [55]. Fine-tuning of coincidence detection [42] is preserved.Back to article page