Functional analysis of microRNA and transcription factor synergistic regulatory network based on identifying regulatory motifs in non-small cell lung cancer

Li, Kening; Li, Zihui; Zhao, Ning; Xu, Yaoqun; Liu, Yongjing; Zhou, Yuanshuai; Shang, Desi; Qiu, Fujun; Zhang, Rui; Chang, Zhiqiang; Xu, Yan

doi:10.1186/1752-0509-7-122

Table 6 Biology process terms regulated by the miRNA-TF synergistic regulatory network

From: Functional analysis of microRNA and transcription factor synergistic regulatory network based on identifying regulatory motifs in non-small cell lung cancer

GO term	Annotation	Rank^a	In motifs^b
GO:0042981	Regulation of apoptosis	1	10
GO:0032268	Regulation of cellular protein metabolic process	2	10
GO:0007167	Enzyme linked receptor protein signaling pathway	3	9/I
GO:0031399	Regulation of protein modification process	4	10
GO:0042325	Regulation of phosphorylation	5	10
GO:0019220	Regulation of phosphate metabolic process	6	10
GO:0051329	Interface of mitotic cell cycle	7	10
GO:0000082	G1/S transition of mitotic cell cycle	8	9/IV
GO:0001932	Regulation of protein phosphorylation	9	10
GO:0007169	Transmembrane receptor protein tyrosine kinase signaling pathway	10	9/I
GO:0071156	Regulation of cell cycle arrest	11	9/IV
GO:0045859	Regulation of protein kinase activity	12	10
GO:0000075	Cell cycle checkpoint	13	9/IV
GO:0006259	DNA metabolic process	14	10
GO:0006281	DNA repair	15	9/IV
GO:0043549	Regulation of kinase activity	16	10
GO:2000045	Regulation of G1/S transition of mitotic cell cycle	17	9/IV
GO:0000084	S phase of mitotic cell cycle	18	9/IV
GO:0051320	S phase	19	9/IV
GO:0007093	Mitotic cell cycle checkpoint	20	9/IV
GO:0031575	Mitotic cell cycle G1/S transition checkpoint	21	8/III, IV
GO:0071779	G1/S transition checkpoint	22	8/III, IV
GO:0006468	Protein phosphorylation	23	9/I
GO:0043066	Negative regulation of apoptosis	24	9/I
GO:0043069	Negative regulation of programmed cell death	25	9/I
GO:0031328	Positive regulation of cellular biosynthetic process	26	9/I
GO:0071900	Regulation of protein serine/threonine kinase activity	27	9/I
GO:0009968	Negative regulation of signal transduction	28	9/I
GO:0048011	Nerve growth factor receptor signaling pathway	29	9/I
GO:0046777	Protein autophosphorylation	30	7/I, II, V
GO:0006355	Regulation of transcription, DNA-dependent	31	9/I
GO:2001141	Regulation of RNA biosynthetic process	32	9/I
GO:0009967	Positive regulation of signal transduction	33	8/I, V
GO:0006357	Regulation of transcription from RNA polymerase II promoter	34	9/I
GO:0043065	Positive regulation of apoptosis	35	9/I
GO:0045893	Positive regulation of transcription, DNA-dependent	36	8/I,III

^aRank: is the rank number calculated using the formula (2.7.1) based on the number of occurrences of the GO terms among all the assigned terms.
^bIn motifs: is how many motif types (subnetworks) were assigned the corresponding GO term. The roman number(s) following the slash indicate the subnetwork(s) in which the corresponding GO term was not found.

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ISSN: 1752-0509

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