Figure 10

Bifurcation diagrams showing the behaviour of the complete UPR model for various stress levels. The boundaries of the three activity states are also shown with horizontal arrows. The black arrows in (a) and (b) indicate the trend for milder stress conditions which are omitted from the plots. Three of the stress conditions have been marked as mild, moderate and severe for use in the analyses. These correspond to the values 12, 15 and 18, respectively, for the rate of total unfolded protein accumulation (mUFPT). The diagrams are plotted as in Figure 9.