Figure 4

The IRE1 α branch of the adaptive response module. The figure shows the activated IRE1 α cleaving the XBP1 mRNA (mXBP1) to yield the spliced XBP1 mRNA (mXBP1s), which translates into the XBP1 protein (XBP1s). There are two sites where the module interacts with external modules (with the ATF6 branch in the model) through regulation. These are drawn in the figure as the external regulators of BiP and XBP1 transcription.