Figure 7

The effect of the ATF6 branch on the adaptive response. The figure shows the total BiP (BiPT) levels with respect to the total unfolded protein (UFPT). The thick black solid curve describes the change from the basal adaptive response, i.e. the thin solid curve, when ATF6 branch is involved. The dashed, dotted, and the hybrid curves, respectively, show the response when transfer or cleavage is inhibited, or when WFS1 is rendered ineffective. The reference model with both ATF6 and XBP1 branches is given in Additional file 1: Text 1.3.