From: Transdifferentiation of pancreatic cells by loss of contact-mediated signaling
Symbol | Description | Value | ||
---|---|---|---|---|
Embryo | Adult | |||
Variables | A | Expression of transcription factor Hnf6 | 1 | 0 |
X | Expression of transcription factor Ngn3 | 0 | 0 | |
Y | Expression of transcription factor Ptf1a | 0 | 1 | |
Z | Expression of transcription factor Isl1 | 0 | 0 | |
| Average Ngn3 expression in neighboring cells | 0 | 0 | |
| Average Ptf1a expression in neighboring cells | 0 | 1 | |
Parameters | a | Strength of lateral inhibition X⊩⊣X | 1000 | |
b | Strength of lateral stabilization Y⇔Y | 2000 | ||
c | Strength of inhibition X⊣Y and Z⊣Y | 500 | ||
q | Strength of induction A→X and A→Y | 10−4 | ||
r | Strength of inhibition Y⊣A and Z⊣A | 100 | ||
s | Strength of autoactivation Z→Z | 50 | ||
n | Hill coefficient, nonlinearity of reactions | 3 | ||
η x | Noise amplitude on X | 10−3 | ||
η y | Noise amplitude on Y | 10−3 |