Figure 6

Disturbance rejection simulation of a mechanistic model. (A) Simulation of a step function disturbance to p53 production. The equations illustrate how the steady-state error and %OS are calculated. (B) Steady-state error and %OS (top panel) and the trade-off curve (bottom panel) when γ increases. (C) Plots of %OS and steady-state error vs. γ with varying Mdm2 levels. (D) Plots of %OS vs. γ with varying time delay. (E) Time delay can cause sustained oscillation (β ₁ =1, β ₂ =1, β ₃ =1, β ₄ =1, α ₁ =1, α ₂ =0.01, α ₃ =1, α ₄ =0.01, n =2, K ₁ =10, K ₂ =100, γ=10^-2- 10²).