Skip to main content

Table 1 Conserved residues among carbamoyltransferases

From: Identifying reaction modules in metabolic pathways: bioinformatic deduction and experimental validation of a new putative route in purine catabolism

Enzyme family

Common TCase motifs

ATCase motif

Ā 

(Positions in Escherichia coli ATCase)

Ā 

1

2

3

4

Ā 

S53-T56

H135-Q138

H265-P268

R230-Q232

OTCase

S[LT]RT

HPXQ

HCLP

--

AOTCase, SOTCase

S[LM]RT

HP[LC]Q

HCLP

--

YTCase

S[LT]RT

HP[TMF]Q

H[AVC]LP

--

abTCase

STRT

HPTQ

HDLP

--

ATCase (I & II)

S[TR]RT

HP[ST]Q

HP[LG]P

RXQ

pseudo-ATCase 1

STRT

HPTQ

HPLA

AIA or AIS or SIA

pseudo-ATCase 2

STRT

HPTQ

H[ST]LP

GX[SC]

pseudo-ATCase 3

STRT

HPTQ

HSLP

VXP

  1. The structural motifs specific for each subgroup of pseudo-ATCases are in bold.