Table 3 Examples of highly weighted side effects for each protein domain inferred by the L1LOG method

1

PF13558

SbcCD_C (Putative exonuclease SbcCD, C subunit)

330.0000

anaphylaxis

41.1178

allergic reaction

2

PF10320

7TM_GPCR_Srsx (Serpentine type 7TM GPCR chemoreceptor Srsx)

330.0000

tardive dyskinesia

216.3340

mental depression

102.3075

regurgitation

100.7863

shortness of breath

90.8773

hyperprolactinemia

3

PF10316

7TM_GPCR_Srbc (Serpentine type 7TM GPCR chemoreceptor Srbc)

330.0000

labyrinthitis

330.0000

nasal congestion

327.1335

burning sensation

266.0200

torticollis

225.7442

testicular swelling

4

PF02898

NO_synthase (Nitric oxide synthase, oxygenase domain)

330.0000

shortness of breath

292.0382

hypoventilation

232.9827

respiratory arrest

229.9422

increased salivation

204.4183

blindness

5

PF10324

7TM_GPCR_Srw (Serpentine type 7TM GPCR chemoreceptor Srw)

330.0000

priapism

330.0000

nasal congestion

330.0000

weakness

325.3147

shortness of breath

279.9735

ptosis

6

PF00191

Annexin (Annexin)

326.7361

glycosuria

117.1047

vasculitis

95.9706

sialadenitis

79.3155

COPD

71.9669

choking

7

PF02931

Neur_chan_LBD (Neurotransmitter-gated ion-channel ligand binding domain)

324.4456

shortness of breath

281.0425

hypoventilation

244.4901

increased salivation

228.2349

respiratory arrest

221.8014

drug dependence

8

PF00060

Lig-chan (Ligand-gated ion channel)

320.0000

anaphylaxis

19.4911

allergic reaction

9

PF08377

MAP2_projctn (MAP2/Tau projection domain)

251.7744

hyperuricemia

145.3436

glycosuria

47.3304

sialadenitis

44.6506

choking

36.2648

polydipsia

10

PF14396

CFTR_R (Cystic fibrosis TM conductance regulator (CFTR), regulator domain)

239.2866

gallbladder disease

212.0452

gynecomastia

156.3952

paronychia

134.2967

prostatism

131.3925

cervical erosion