Figure 5

Central metabolism of Saccharomyces cerevisiae. during diauxic shift. A) Scheme of pathway of the central metabolism of Saccharomyces cerevisiae. B) Metabolite dynamics and enzyme activation profiles corresponding to the maximization of the survival time of S. cerevisiae under diauxic shift (see Equation (33)). Metabolites and enzymes are expressed in arbitrary units. C) Pareto front for the maximization of the survival time and the minimization of the enzyme consumption of S. cerevisiae under diauxic shift (Equation (40)). Optimal profiles have been approximated to 8 linear elements with variable length. D) Comparison between experimental data and model predictions for the SC example for point O. E) Evolution of e ₅ for the selected points.