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Table 4 The top 10 most upregulated genes following transfection and expression of Rnf14 variant 3 and variant 1 transcripts in C2C12 cells

From: RNF14 is a regulator of mitochondrial and immune function in muscle

Rnf14 variant 3 versus controls

Gene ontology

Fold change (Log2)

Ifit3

Interferon induced protein

2.22

G1p2

Interferon induced protein

2.20

2510004L01Rik (RSAD2)

Interferon inducible

2.09

Oasl2

2'-5'-oligoadenylate synthetase activity

1.97

2310061N23Rik (Ifi27l2a)

Interferon inducible

1.96

Ccl5

Chemokine ligand 5

1.91

AI481100 (Irgm2)

Interferon induced GTPase

1.84

Usp18

A member of the deubiquitinating protease family of enzymes

1.76

Rnf14

This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression

1.75

Gbp4

Induced by interferon and hydrolyzes GTP

1.73

Rnf14 variant 1 versus controls

Gene ontology

 

Plac8

Placenta-specific, little known

2.07

G1p2

Interferon induced protein

1.99

Oasl2

2'-5'-oligoadenylate synthetase activity

1.82

Ccl5

Chemokine ligand 5

1.68

LOC223672 (Apol9a)

Apolipoprotein, little known

1.65

2510004L01Rik

Interferon inducible

1.61

2310016F22Rik (Apol9b)

Apolipoprotein, little known

1.54

ifit3

Interferon induced protein

1.42

Gbp4

Guanylate-binding proteins induced by interferon

1.30

Oasl1

2'-5'-oligoadenylate synthetase activity

1.21

  1. Genes may be represented by more than one probe. The controls are a combination of untransfected cells and cells transfected with an empty construct.