Influence networks based on coexpression improve drug target discovery for the development of novel cancer therapeutics

Table 1 Most influential genes

	Untreated		14 Days Letrozole		90 Days Letrozole
Rank	Entrez ID	Gene symbol	Entrez ID	Gene symbol	Entrez ID	Gene symbol
1	28978	TMEM14A	79776	ZFHX4	1727	CYB5R3
2	1843	DUSP1	4701	NDUFA7	7083	TK1
3	51022	GLRX2	715	C1R	1292	COL6A2
4	1434	CSE1L	79818	ZNF552	857	CAV1
5	8522	GAS7	4046	LSP1	5437	POLR2H
6	51668	HSPB11	1727	CYB5R3	9833	MELK
7	10456	HAX1	357	SHROOM2	54861	SNRK
8	9902	MRC2	283298	OLFML1	4830	NME1
9	4706	NDUFAB1	23179	RGL1	231	AKR1B1
10	23560	GTPBP4	1809	DPYSL3	10418	SPON1
11	79633	FAT4	857	CAV1	2350	FOLR2
12	10418	SPON1	274	BIN1	10979	FERMT2
13	471	ATIC	79833	GEMIN6	11096	ADAMTS5
14	6403	SELP	11222	MRPL3	4638	MYLK
15	23421	ITGB3BP	23244	PDS5A	9448	MAP4K4
16	23452	ANGPTL2	6241	RRM2	54922	RASIP1
17	54861	SNRK	1289	COL5A1	6934	TCF7L2
18	2034	EPAS1	8434	RECK	4072	EPCAM
19	30008	EFEMP2	429	ASCL1	4701	NDUFA7
20	25999	CLIP3	3426	CFI	404672	GTF2H5
21	4311	MME	332	BIRC5	6241	RRM2
22	4747	NEFL	2	A2M	2192	FBLN1
23	1809	DPYSL3	10730	YME1L1	25959	KANK2
24	28998	MRPL13	11130	ZWINT	55651	NHP2
25	25959	KANK2	1292	COL6A2	5050	PAFAH1B3

Lists of the top 25 of most influential genes in influence networks based on coexpression among genes in ER ⁺ breast tumors before, during, and after a course of neoadjuvant treatment with the drug letrozole. Bold font indicates genes that are also classified as hub-bottleneck genes.

ISSN: 1752-0509