Detection of driver metabolites in the human liver metabolic network using structural controllability analysis

BMC Systems Biology

Table 2 The list of the critical driver metabolites in the HLMN

Metabolite name	Metabolite description	Category
5dhf[e]	pentaglutamyl folate (DHF)	FEM[31]
5thf[e]	pentaglutamyl folate (THF)	FEM[31]
ach[e]	Acetylcholine	FEM[32]
adp[e]	ADP	UM[33]
arg-DASH-L[e]	L-Arginine	UM[33]
asp-DASH-L[e]	L-Aspartate	UM[33]
atp[e]	ATP	UM[33]
avite1[e]	alpha-Tocopherol	FEM[34]
biocyt[e]	Biocytin	FEM[35]
cmp[e]	CMP	UM[33]
fe3[e]	Fe 3+	FEM[36]
glygn2[e]	glycogen, structure 2	EUM
gtp[e]	GTP	UM[33]
ha[e]	hyaluronan	FEM[37]
idp[e]	IDP	FEM[38]
ksi[e]	keratan sulfate I	EUM
lcts[e]	Lactose	EUM
Lcystin[e]	L-Cystine	FEM[39]
met-DASH-L[e]	L-Methionine	UM[33]
nac[e]	Nicotinate	EUM
nad[e]	Nicotinamide adenine dinucleotide	UM[33]
nadp[e]	Nicotinamide adenine dinucleotide phosphate	UM[33]
orn[e]	Ornithine	EUM
paf-hs[e]	1-alkyl 2-acteylglycerol 3-phosphocholine	FEM[40, 41]
pe-hs[e]	phosphatidylethanolamine	FEM[42, 43]
pglyc-hs[e]	phosphatidylglycerol	EUM
pnto-DASH-R[e]	(R)-Pantothenate	FEM[44]
ppa[e]	Propionate (n-C3:0)	FEM[45]
s2l2fn2m2masn[e]	PA6	EUM
strch1[e]	starch, structure 1	FEM[46]
sucr[e]	Sucrose	FEM[47]
tagat-DASH-D[e]	D-Tagatose	EUM
tag-hs[e]	triacylglycerol	FEM[48]
ttdca[e]	tetradecanoate (n-C14:0)	EUM
utp[e]	UTP	UM[33]
yvite[e]	gamma-Tocopherol	FEM[49, 50]

The compartment abbreviation of all critical driver metabolites are "[e]", which means that their locations are all extracellular. The in-degree of each critical driver metabolite is zero, which implies that each critical driver metabolite is the start metabolite of a metabolic pathway. The categories "UM", "FEM", "EUM" respectively represent the universal metabolites, the functional essential metabolites and the metabolites whose essentiality have not been discovered.

ISSN: 1752-0509