Figure 4From: Disentangling the multigenic and pleiotropic nature of molecular functionSemantic similarity of GO annotations within/between functional and enriched profiles. The solid blue line shows the frequency of distances between pairs of GO terms within each pathway's functional profile. The solid green line shows the frequency of distances between pairs of GO terms within each pathway's enriched profile. Annotations in functional profiles were merged and distance frequencies are shown by the dashed blue line. This process was repeated for the enriched profiles to create the dashed green line. Merging profiles gives the random expected distance between annotations, controlling for annotation frequencies. When merging profiles annotations appear multiple times, however, annotations were not compared to themselves.Back to article page