A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress

Table 4 Changes in Gene expression of key factors in 1× IMO samples

Name	Change via microarray	mRNA verified	Protein verified
Egr1	⇮ ⇮ ⇮	⇮ ⇮ ⇮	⇮ [25],[30]
CREM	⇮ ⇮ ⇮	-	-
DBH	Not changed	⇮ [2]	Not changed
DUSP14	⇮ ⇮	-	-
Egfr	⇮ ⇮	⇮ ⇮	-
Fos	⇮ ⇮ ⇮	⇮ ⇮ ⇮	Yes [31],[32]
Jun	⇮ ⇮	⇮	-
MAPKAP2	⇮ ⇮	⇮ ⇮ ⇮	-
Stat3	⇮ ⇮	⇮ ⇮	-
Inhibitor of activated Stat3 (PIAS3)	⇮	-	-

Upward or downward-pointing arrows symbolize the following: ⇮changed up to 2.5 fold. ⇮⇮ 2.5 to 10.0 fold. ⇮⇮⇮ greater than 10.0 fold. Changes in mRNA levels were confirmed by Northern Blot, qRT-PCR or Real Time PCR array.

ISSN: 1752-0509