Table 5 Top genes ranked by the RWR algorithm in an expanded PPI network “BioGrid+PRDM9” and their semantic similarity to two recombination related GO terms
BioGrid+PRDM9 | BioGrid | |||
|---|---|---|---|---|
Rank | Genes | Similarity | Genes | Similarity |
1 | KPNA2 | 0.712 | KPNA2 | 0.712 |
2 | UIMC1 | 0.464 | UIMC1 | 0.464 |
3 | FBXW11 | 0.458 | FBXW11 | 0.458 |
4 | UBC | 0.806 | UBC | 0.806 |
5 | EP300 | 0.548 | EP300 | 0.548 |
6 | SMARCA4 | 0.417 | SMARCA4 | 0.417 |
7 | SMAD3 | 0.438 | SMAD3 | 0.438 |
8 | HDAC1 | 0.502 | HDAC1 | 0.502 |
9 | H2AFX | 0.838 | POLR2A | 0.425 |
10 | POLR2A | 0.425 | SMAD2 | 0.432 |
11 | H3F3A | 0.301 | CREBBP | 0.378 |
12 | SMAD2 | 0.432 | RUNX1 | 0.392 |
13 | CREBBP | 0.378 | SMAD4 | 0.457 |
14 | RUNX1 | 0.392 | SUMO1 | 0.432 |
15 | SMAD4 | 0.457 | DAXX | 0.495 |
16 | H3F3B | 0.301 | ID3 | 0.509 |
17 | SPO11 | 0.883 | MYB | 0.568 |
18 | SPATA17 | 0 | PARP1 | 0.414 |
19 | RNF212 | 0.668 | RXRA | 0.368 |
20 | SUMO1 | 0.432 | TAT | 0.263 |
Average | 0.493 | 0.474 | ||