Figure 3From: The role of TGF-β signaling and apoptosis in innate and adaptive immunity in zebrafish: a systems biology approach Interactions of Acvr1b with other proteins in primary infection. Acvr1b was identified to be a hub protein during both primary and secondary infection. The R-SMAD Smad2 was found to be a key protein in primary infection. The identification of R-SMAD in both primary and secondary infection suggests that the activation of TGF-β signaling requires the SMAD pathway.Back to article page