Figure 3
From: Understanding disease mechanisms with models of signaling pathway activities
Signaling changes in mouse models of obesity. A) Activation within the Wnt pathway of circuits triggering cell cycle, in particular the Wnt/β-catenin, when wildtype mice 16 weeks old is compared to wildtype 5 weeks old, and B) Activation of different circuits of the apoptosis pathway in Ob/Ob 16 week mice when compared to the 16 week wildtype mice. Red nodes label activated circuits with respect to initial state of each comparison and blue nodes label deactivations. Solid lines indicate activations and dashed lines indicate inhibitions.