Figure 2

Construction of toxicity functions exemplified by the high-CHOEP regimen and its toxic effect on stem cells. The Heavyside functions for a single application of the combination of Cyclophosphamide, Doxorubicin and Vincristin (at time point 0) and for single Etoposide (applications at time points 0, 1 and 2) are determined (first column), delayed (second column) and multiplied with the corresponding stem cell toxicity factors (third column). Finally, the functions were added resulting in the overall toxicity function.