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Table 2 Number of cyclical EFMs associated with each cofactor

From: Discovery of substrate cycles in large scale metabolic networks using hierarchical modularity

Cofactor

Number of cyclical EFMs: net consumed

Number of cyclical EFMs: net produced

H+(c)

70504

70446

H+(m)

70446

70504

Pi(c)

55051

55102

Pi(m)

55051

55055

Sulfate(c)

33046

33046

Sulfate(m)

33046

33046

Sulfite(c)

33046

33046

Sulfite(m)

33046

33046

H2O(c)

15015

14960

H2O(m)

14958

14956

ATP(c)

155

217

ADP(c)

208

152

dATP(c)

143

120

UDP(c)

106

151

dUTP(c)

155

96

CTP(c)

94

47

CDP(c)

57

82

GDP(c)

59

59

dGTP(c)

58

58

GTP(c)

69

45

dGDP(c)

44

68

dAMP(c)

27

37

dUDP(c)

25

37

dCTP(c)

23

35

dCDP(c)

23

35

NAD+(c)

24

24

NADH(c)

24

24

NADPH(c)

19

20

NADP+(c)

20

19

PPi (c)

3

24

  1. For each of the top 30 cofactors that most frequently participate in a cyclical EFM (column 1), the table reports the number of cyclical EFMs that consume (column 2) or produce (column 3) the cofactor. The cofactors are sorted in descending order based on the total number of cyclical EFMs in which they participate. The letter in the parentheses indicates the cellular compartment for each cofactor as either cytosolic (c) or mitochondrial (m).