Fig. 2

Using DeDaL for visualizing the network and RNA-Seq expression data of tissue-specific genes. RNA-Seq dataset for 27 healthy human tissues was used to defined a subnetwork of HPRD PPI database enriched in tissue-specific genes (see the text for explanations). Network smoothing followed by computation of principal manifold was applied to produce the data-driven network layout (DDL). Patterns of gene expression for two selected tissues (brain and spleen) are shown on top the constructed DDL, red color denotes higher expression, green color corresponds to lower expression. The sizes of the nodes are proportional to their connectivity degree in this network. On the left top panel application of the Force Directed layout is shown for comparison. On the left bottom panel results of quantitative comparison between multidimensional distance representation in DeDaL and Force Directed layout are shown. The most representative distances between the genes in the initial multidimensional space (see [28] for details) are ranked here from the largest to the smallest values