Fig. 1

Copy Number alterations. WT cell, since diploid organisms, carry two copies of each gene (red segments). Deletions in tumour cells lead to no copy (CN = 0) or one copy (CN = 1) of this section of DNA, rather than two copies (CN = 2). Amplifications in tumour cells lead to three (CN = 3) or more copies (CN = 4) of DNA section