Reconstruction of gene networks using prior knowledge

BMC Systems Biology

Table 1 Comparison of MEN, BBSR and PriorPC in terms of AUPRC

	DREAM4	E. coli	B.subtilis	Using TS
MEN_low	0.48	0.201	0.218	Yes
MEN_high	0.571	0.347	0.369	Yes
BBSR_low	0.44	0.196	0.269	Yes
BBSR_high	0.519	0.359	0.394	Yes
PriorPC (α=1)	0.328	0.413	0.392	No
PriorPC (α=0.75)	0.341	0.336	0.303	No

For all three methods, 50 % of the edges present in the gold standard network were randomly selected and assigned a true prior (1 for MEN and BBSR, a random probability in (0.5,1] for PriorPC). For PriorPC, α is given in brackets. MEN and BBSR also use time-series(TS) data. Results are comparable across the three algorithms

ISSN: 1752-0509