Table 2 Comparison of methods to regulate FBA
From: FlexFlux: combining metabolic flux and regulatory network analyses
Method | Associated software | Requires | Dynamic | Steady-state | Multistate | Regulatory | Network |
|---|---|---|---|---|---|---|---|
external data | analysis | analysis | support | loops support | inference | ||
RSA + FBA | Yes (FlexFlux) | No | No | Yes | Yes | Yes | No |
RFBA | Yes (COBRA and FlexFlux) | No | Yes | No | COBRA: No FlexFlux: Yes | Yes | No |
SRFBA | No | No | No | Yes | No | No | No |
iFBA | No | No | Yes | No | No | Yes | No |
PROM | No | Yes | Yes | No | No | Yes | Yes |