Fig. 3

Pores far from a channel in a region with a low diffusion constant have a negligible contribution to Ca²⁺ transmission across the NE. Pores are distributed on the great arc between a channel C on the ONM and a measurement location P _N on the nuclear side. Ca²⁺ levels are given as a fraction of the released amount. The panel b shows the pores arrangement between the channel C and the point P _N : each additional pore occupies the following place on a queue that starts close to C. Panel a the transmitted Ca²⁺ as a function of the number of pores. Panels c For the case of 48 pores, their contribution as a function of their distance to the channel C. The different points along a vertical line correspond to different times. Pores far from the site located on the side with a low diffusion constant have a negligible or even slightly negative contribution. We sum the contributions over time of an individual pore, up until the time where the calcium concentration at P _N reaches its maximum value. The results in panels c show the fraction contributed by a pore, in relation to the total contribution by all the pores α=0.15