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Fig. 6 | BMC Systems Biology

Fig. 6

From: An efficient algorithm for identifying primary phenotype attractors of a large-scale Boolean network

Fig. 6

Simplified MAPK network for apoptosis attractors. When finding attractors for apoptosis in the MAPK model, the original update rules for MAPK network is divided into two parts. The first is fixed state values of ESENs and PSPNs. The second is the simplified update rules for nodes (N) except both ESENs and PSPNs. The network in this figure is the hierarchically partitioned network for the nodes N with the simplified update rules. There exist only two SCCs V 1,1 and V 3,1 that have more than one node. The nodes in V 1,1 and V 3,1 are colored with green and red, respectively. In this case there exist no constraints, so that there are no yellow boxes as in Fig. 5

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